As the COVID-19 pandemic led to the spread of remote work environments, a paradigm shift in workplace and work style has occurred, and “hybrid work,” referring to the combination of remote work and office work, has attracted attention as a novel way of working. At this juncture when interest in hybrid work continues to remain high, it is necessary to verify the impact on workers’ productivity and corporate competitiveness in real-life work environments. This study aims to explore the facilitating factors and effectiveness of hybrid work and derive related implications based on qualitative research methodology. To this end, in-depth interviews were conducted with 12 employees who have experience using the hybrid work system at ten large domestic firms and foreign companies. Interview questions were formulated based on factors extracted though literature review. The application process of the hybrid work rule and conditions for its successful implementation were analyzed through the procedural structure of grounded theory. As a result, a series of patterns were identified that indicate the transition from remote to hybrid work and subsequent changes in work format have an overall positive impact on employees and organizations. The results demonstrate that in order to facilitate hybrid work, it is critical to simultaneously consider technological, institutional and human factors. Specifically, to enable work without the constraints of time and place, collaborative solutions and digital technology should be strengthened while organizational culture and personnel policies should also improve in line with the changes in work format. In addition, strong support from top management is absolutely necessary for the successful establishment of a hybrid work system. Furthermore, workers at companies where hybrid work is encouraged said they most valued the opportunity to choose between working from home and going to the office depending on the nature of their work. This means that transitioning from an office-centered to a people-centered workplace and providing a flexible working environment leads to improved quality of life and higher productivity for workers as well as their increased willingness to stay with the company, resulting in a virtuous cycle of enhanced corporate competitiveness. This study uses a qualitative research method to analyze the implementation and effects of the hybrid work scheme from a process-oriented perspective and offers practical implications based on actual experiences of workers, which significantly sets it apart from previous studies.